(421f) Removal Dissolved Metal Impurities from API Stream Using Functionalized Silica Resins in a Packed Column

In recent years, the number of applications of transition metal-catalyzed transformations have increased due to their selectivity towards the desired product. Subsequently, the removal of metal residue from the reaction mixtures has become a challenge in the pharmaceutical industry. Purification of APIs from residual metal by traditional methods (chromatography, activated carbon, etc.) often leads to problems such as high costs, long cycle times, low efficiency, and reduced API yields. In the present work, we have demonstrated an application of a packed column with functionalized silica resin for removal of metal from an API stream. Present work shows initial screening at batch scale to identify ideal resin and then further optimization using a packed column to achieve desired metal removal from API stream. This study will also focus on the scale-up considerations for metal removal processes, optimization of process parameters (such as residence time and temperature), and modes of operation (re-circulation vs single-pass).

Disclosures:

All authors are employees of AbbVie and may own AbbVie stock. AbbVie sponsored and funded the study; contributed to the design; participated in the collection, analysis, and interpretation of data, and in writing, reviewing, and approval of the final publication.