(213g) The Pathophysiological Effects of Fluid-Structure Interaction of Species Transported and Transformed from Ambient to Human Respiratory System

The physiological system in humans consist of several organs that are structured to relate chemically and physically with complex fluids which aid to carry different nutrients and gaseous species (oxygen) necessary for proper functioning of the human system. However, the quality of the ambient atmosphere and its physiological end effect plays a tremendous role in determining homeostasis (stability) of the human body systems. For instance, anthropological alteration of the quality of air such as incomplete combustion of hydrocarbon can lead to release of injurious gases such as carbon monoxide and if inhale by human can distort the composition of blood leading to the formation carboxyhemoglobin. This physiological distortion is fatal in its consequence. Furthermore, with the increased interest in correlating ambient fluid quality with human pathophysiological conditions, it has become immensely significant to understand the mechanism of species transported and transformed via the respiratory tract, the major gateway to human complex systems. Thus, the research is aimed at studying the pathophysiological impact of ambient species on human physiological system through detail analysis of the flow process of species and its mechanism of interaction as they are transported from the bulk ambient fluid to the respiratory organs. A detail qualitative study will be conducted to gather data on the composition of the ambient atmospheric fluids at different geographical locations and coupled these data into modelling platform designed to study the mechanism of transportation and transformation of species as they interact with the organs of the respiratory system. The goal of this work is to develop a prognosticative and diagnostic modelling platform that can successfully analyze and predict the pathophysiological effects of ambient fluid on human systems while offering suggestions on range of preventive and therapeutic measures to correct these physiological anomalies.