(290h) Chromium Chelated Carrageenan: An Investigation of Physicochemical Properties, Toxicity, and Antimicrobial Potential through Computational and Experimental Approach

Carrageenan (car-) was extracted from Eucheuma isoforme and chelated with chromium ions (Cr³⁺) were computationally and experimentally tested for their physicochemical properties, prediction analysis, toxicity, and antimicrobial potential. The bacterial and leishmanial inhibition studies of car- were conducted through agar-well diffusion method and direct counting-assay whereas Computational techniques such as PatchDock, SwissADME, Molinspiration, and GUSAR were utilized to establish theoretical background to assess its inhibition action on microbial proteins, toxicity and medicinal properties. Cr³⁺ adsorption demonstrated covalent bonding and confirmed through best fit for Freundlich and Dubinin-Radushkevich models. Docking studies proved that car- components have good inhibitory activity for the bacterial and leishmanial proteins. Whereas the prediction analysis and toxicity studies showed that the friendliness of these molecules for the human body is enormous. Thus, it has been proved that car- is a perfect candidate for antibacterial and antileishmanial activity.