(348m) Membrane Assisted Antisolvent Crystallization: Process Simulation and Control

Lei Sheng, Jin Li, Gaohong He, Xiaobin Jiang*

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Engineering Laboratory for Petrochemical Energy-efficient Separation Technology of Liaoning Province, Dalian University of Technology, Dalian, 116024, China

E-mail: xbjiang@dlut.edu.cn

ABSTRACT: Antisolvent crystallization is an important purification technology for the pharmaceutical and fine chemical industry. Herein, we investigated the mass transfer mechanism of membrane-assisted antisolvent crystallization (MAAC) and developed the multistage operation to reinforce the manufacture feature of antisolvent crystallization. Computational fluid dynamics simulation results via developed mathematics model and the experimental images via in-situ detecting technology jointly illustrated the advantages of MAAC on accurate mass transfer control. Multistage MAAC that intensifying the product capacity under a stable control is a promising direction for the new generation antisolvent crystallization.

Figure 1. (a) Schematic diagram of MAAC process with key parameters; (b) observed images of the antisolvent liquid layer, the membrane outer surface at different crystallization with increasing suspension crystal density (from left to right).