(591g) Real Time, Dynamic (Non-Steady State) Process Models for Osd Continuous Manufacturing Control

The creation of a dynamic, real-time, mass balanced based process model for a continuous, direct blend encapsulation line will be discussed. The ability to control the response of a continuous process to deviations in feeder rate is a critical aspect of all oral solid dosage form continuous manufacturing systems. Real time modeling is a robust and flexible approach for this type of control strategy. This type of dynamic modeling can predict concentration changes in the system simultaneously with changes in throughput and hold up mass with as few as two fit parameters.