(5f) Positive and Negative Chemotaxis of Enzyme-Coated Liposomes
AIChE Annual Meeting
2020
2020 Virtual AIChE Annual Meeting
Engineering Sciences and Fundamentals
Active Colloidal Systems I
Monday, November 16, 2020 - 9:15am to 9:30am
Directional migration in response to specific chemical signals is critical for the survival of biological organisms. This enables living cells to move towards food, escape away from toxins, transport cargo and coordinate collective behavior. Model protocells derived from phospholipids and other amphiphiles have been studied and their movement through catalysis has been observed. However, control of directionality based on chemical cues (chemotaxis) has been difficult to achieve. In this presentation, I will discuss both positive and negative chemotaxis of liposomal protocells based on the interplay between positive enzymatic catalysis-induced chemotaxis and solute-phospholipid interaction-based negative chemotaxis. Additionally, I will show how we can direct the movement of the liposomal motors by changing the composition of the lipid bilayer itself. In doing so, we systematically rule out currently available mechanisms of colloidal transport and propose a potentially new and previously unrecognized mechanism of transport due to the Hofmeister effect. This opens up the possibility of other mechanisms for the transport of biological colloids.
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