(210a) Invited Talk: Taking Electrochemical Biomolecular Sensors from the Bench to the Clinic

To put disease-related biomarkers to work in the clinic, new high-performance technologies are needed to enable rapid and sensitive analysis of clinical specimens. Electrochemical methods providing low cost and direct biomarker readout have attracted a great deal of attention for this application. In our laboratories, we have used controlled nanostructuring of electrode surfaces to enhance biomolecular capture rates and efficiencies (J. Am. Chem. Soc. 2017). By immobilizing biomolecules on nanostructured surfaces, high-performance biomolecular detection systems can be developed to facilitate rapid biomarker analysis and the detection of infectious pathogens (J. Phys. Chem. C. 2016; Nano Lett. 2017). We have developed electrochemical assays that are able to detect nucleic acids, proteins and small molecules, with universally high sensitivity levels and have applied this approach in a variety of areas including noninvasive monitoring via Liquid Biopsy (Nature Chemistry 2015) and antimicrobial resistance assessment (Nature Chemistry 2020). Recently we have developed reagentless sensors that are powerful detectors for viral sensing (J. Am. Chem. Soc. 2021) and in vivo sensing (Nature Chemistry, 2021). This talk will summarize the development of these sensors, their application to a variety of clinical problems, and their evolution into a clinical-grade products.