(232a) Cellular Hitchhiking for Targeting Nanoparticles
AIChE Annual Meeting
2021
2021 Annual Meeting
Nanoscale Science and Engineering Forum
Area Plenary: Bionanotechnology (Invited Talks)
Tuesday, November 9, 2021 - 8:00am to 8:50am
Nanoparticle-based drug delivery systems are widely explored to improve the biological outcome of chemo and immunotherapy. However, poor vascular circulation, limited targeting, and the inability to negotiate many biological barriers are key hurdles in their clinical translation. Biology has provided many examples of successful âcarriersâ in the form of circulatory cells, which routinely overcome the hurdles faced by synthetic nanoparticle systems. Our laboratory has explored blood-cell inspired drug delivery systems that take advantage of the abilities of red blood cells and macrophages. We have explored âcellular hitchhikingâ which involves combining synthetic particles with circulatory cells to drastically alter the in vivo fate of the synthetic particles. I will provide an overview of the principles and two examples of hitchhiking-based nanoparticle delivery.