(283a) Leveraging First Principles to Advance Downstream Process Development and Understanding for Biologics
AIChE Annual Meeting
2021
2021 Annual Meeting
Separations Division
Advances in bioseparations
Tuesday, November 9, 2021 - 12:30pm to 1:10pm
This talk will highlight ways that leveraging chemical engineering fundamentals can lead to more advanced process understanding and next generation development workflows. Specific examples include: i) predicting scale-up chromatography performance from miniature column data with the assistance of mechanistic models, ii) building a tangential flow filtration scale down mode using pressure drop as a scaling factor, iii) guiding the selection of harvest membranes or diafiltration buffer compositions, iv) understanding the impact of process variation on downstream unit operations and v) making informed choices for parameter classifications for process characterization. The insights gained in these case studies were the result of an intentional strategy to integrate first principles understanding with data-rich, high-throughput experimentation.