(431e) Recent Enhanced Structural Stress and Tensor Upgrades to Mhawb Tevp Model for Characterization of Human Blood
AIChE Annual Meeting
2021
2021 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Large-Scale Models in Systems Biology
Wednesday, November 10, 2021 - 9:12am to 9:30am
This effort is followed with a discussion of novel transient flow rheological experiments applied to human blood including for model fitting purposes including step-up/step-down, and triangle ramp experiments [7-10]. The family of models that can handle these transient flows involve modifications to the recently published mHAWB model [1-11]. We fist discuss the development of the scalar, structure parameter evolution models and we compare fitting results with our newly acquired transient blood data to the models [5,11]. We also highlight our novel model fitting procedure by first fitting to steady state, and while keeping the steady state parameters constant fitting the remaining model transient parameters to a series of step up/down in shear rate experiments. With the full set of parameters determined with a global, stochastic optimization algorithm the SAOS, LAOS and unidirectional oscillatory shear flow is predicted and compared to the data. Model efficacy is then compared.
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