(472b) Breakage Facilitated Mixed-Suspension, Mixed-Product-Removal (MSMPR) Crystallization

Continuous crystallization provides advantages of producing solid products with desired quality with smaller footprint. However, the intrinsic nucleation and growth rates of small molecule pharmaceuticals constrain the design spaces of the ranges of robust operation conditions and product properties. In this work, a wet-milling device, used to break large particles into small fragments, was incorporated to MSMSR single stage crystallization. The MSMPR crystallization was controlled by a feedback loop in order to maintain a constant total slurry volume. The approach was applied to paracetamol to demonstrate the effectiveness. Experimental data showed that the introduction of the controllable breakage mechanism offered better particle size distribution control and minimized fouling that resulted in longer operation time than conventional MSMPR.

Ref:

Li, H.; Yang, B.-S. Model Evaluation of Particle Breakage Facilitated Process Intensification for Mixed-Suspension-Mixed-Product-Removal (MSMPR) Crystallization. Chem. Eng. Sci. 2019, 207, 1175– 1186, DOI: 10.1016/j.ces.2019.07.030