(58a) Developing a Workflow for Continuous Centrifugal Extraction
AIChE Annual Meeting
2021
2021 Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Continuous Drug Substance and Drug Product – Single Unit Operations - Session 1
Monday, November 15, 2021 - 8:00am to 8:20am
Continuous extraction offers attractive, practical solutions to conventional batch extraction. First, continuous flow devices have smaller footprints compared to batch devices. Additionally, there are many types of flow contacting devices, such as mixer-settlers, packed or agitated columns, and membranes, among others, allowing flexibility for the contacting device to match the properties and needs of the two liquids in the process. One such continuous flow contacting device is a centrifugal extractor. These devices provide excellent mixing for the two liquids as they flow into the device while efficiently separating the two liquids via centrifugal force as they flow out of the device. Centrifugal extractors offer mixing and separation in the same unit to minimize the footprint, can separate liquids with small density differences, can tolerate liquids that tend to emulsify, and provide short contacting times for fast extractions or unstable intermediates. These advantages of centrifugal extractors make them attractive as options for continuous flow in the pharmaceutical industry.
This presentation describes the development work of a model system for continuous centrifugal extraction. We will describe the key features of the process, such as partition coefficient, number of equilibrium stages, and other relevant thermodynamic data. Additionally, we will highlight some of the key issues and parameters to address with scale-up and design of centrifugal extraction processes. Finally, we will detail AbbVieâs general workflow to designing and developing continuous extractions with the goal of implementing robust continuous extractions at scale.
Eric Moschetta and Benjamin Rizkin are employees of AbbVie and may own AbbVie stock. AbbVie sponsored and funded the study; contributed to the design; participated in the collection, analysis, and interpretation of data, and in writing, reviewing, and approval of the final publication.