(758c) Engineering targeted therapeutics for triple negative breast cancer
AIChE Annual Meeting
2021
2021 Annual Meeting
Regenerative Engineering Society
Recent Progress in Biomaterials Innovation and Translation II (Invited Talks)
Thursday, November 18, 2021 - 4:25pm to 4:45pm
My lab engineers targeted drug delivery vehicles in an effort to alter biodistribution and alter cell signaling. Cells organize proteins and lipids to govern adhesion and migration. From this knowledge, my lab synthesizes drug delivery vehicles to achieve strong, cooperative binding. These strategies are employed in inflammation and triple negative breast cancer. My lab has identified a new target and biomarker for triple negative breast cancer, examined the role of ligand/receptor cell adhesion by atomic force microscopy, and synthesized targeted drug delivery vehicles that demonstrate that nanoparticle ligand surface density alters gene expression.