(758c) Engineering targeted therapeutics for triple negative breast cancer | AIChE

(758c) Engineering targeted therapeutics for triple negative breast cancer

Authors 

Auguste, D. - Presenter, Northeastern University
My lab engineers targeted drug delivery vehicles in an effort to alter biodistribution and alter cell signaling. Cells organize proteins and lipids to govern adhesion and migration. From this knowledge, my lab synthesizes drug delivery vehicles to achieve strong, cooperative binding. These strategies are employed in inflammation and triple negative breast cancer. My lab has identified a new target and biomarker for triple negative breast cancer, examined the role of ligand/receptor cell adhesion by atomic force microscopy, and synthesized targeted drug delivery vehicles that demonstrate that nanoparticle ligand surface density alters gene expression.

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