(164y) The Change of Magnetic Susceptibility of Red Blood Cells Depending on the Density.

Currently, clinical blood test focuses on the measuring the number or concentration of hemoglobin (Hb) in blood. However, the main function of Hb is combination of iron ion with oxygens for gas exchange in cells. Subsequently, the combination ability of Hb can be a criterion for biological problem. The change of magnetic susceptibility of Hb shows the red blood cells have different mobility in magnetic field depending on the combination with oxygen. In the case of combination with oxygen, the iron ions have covalent bond and diamagnetic property, which moves opposite direction from magnetic field. Otherwise, the iron ions have unpaired electrons and paramagnetic property, which moves the same direction following magnetic force. To examine the magnetic susceptibilities of red blood cells, the cell tracking velocimetry (CTV) was used. Dragged by magnetic and gravitational force, the red blood cells show different mobility depending on the shape of cells or the concentration of Hb cells by cells during the CTV analyze. Moreover, the density can be used as a measure of disease diagnosis of red blood cells. For example, the blood cell from sickle cell disease has larger densities than normal blood cell. Also, normal red blood cells have a narrow density distribution whereas sickle cells have a relatively wider density distribution. Therefore, the change in the magnetic susceptibility of red blood cells according to the density is investigated, and the probability of using this property for disease diagnosis will be discussed.