(309e) Computational Studies Reveal Varied Mechanisms of Oncogenic Activation amidst a Varied Mutational Landscape in Cancer Patients
AIChE Annual Meeting
2022
2022 Annual Meeting
Engineering Sciences and Fundamentals
Honorary sessions for Keith Gubbins' 85th birthday
Tuesday, November 15, 2022 - 1:42pm to 2:00pm
We acknowledge financial support from the NIH and computational support from the XSEDE and the Flatiron Institute.
References
1. ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma, D. Weiser, S. Bressler, P. J. Huwe, R. Radhakrishnan, M. A. Lemmon, Y. Mosse, Cancer Cell,
2014, 26, 682-694. DOI: 10.1016/j.ccell.2014.09.019. PMC4269829.
2. Computational Algorithms for In Silico Profiling of Activating Mutations in Cancer, E. Jordan, K. Patil, K. Suresh, J. Park, Y. Mosse, M. A. Lemmon, R. Radhakrishnan, 2019, Cellular and Molecular Life Sciences,
76(14):2663-2679; DOI: 10.1007/s00018-019-03097-2. PMID: 30982079. PMCID: PMC6589134.
3. Computational Studies of Anaplastic Lymphoma Kinase Mutations Reveal Common Mechanisms of Activation Amidst a Varied Mutational Landscape in Neuroblastoma Patients, K. Patil, E. J. Jordan, J. Park, K. Suresh, C. M Smith, A. A Lemmon, Y. P. Mosse, M. A. Lemmon, R. Radhakrishnan, 2021, Proceedings of the National Academy of Sciences, 118(10) e2019132118; DOI: 10.1073/pnas.2019132118. PMID: 33674381; PMCID: PMC7958353;