(567a) Pharma 4.0: Advanced Continuous Pharmaceutical Tablet Manufacturing Process

Currently, Industry 4.0 concepts are being applied to pharma industry to achieve Pharma 4.0 paradigm. Pharma 4.0 reduces the time and resources needed for continuous pharmaceutical manufacturing and also improves the product quality and production consistency. It has many advantages but also have bigger challenges on the applications of artificial intelligence (AI)/machine learning (ML), material traceability, optimization, advanced process control, and cyber-physical security side because of the different levels of complexities involved [1-3]. The predictive capabilities and the quality of the pharmaceutical products can be improved significantly via employing the artificial intelligence and the advanced model predictive control (MPC) system if an appropriate cyber-physical security defense is in place.

In this work, five components of industry 4.0 namely artificial intelligence (AI)/machine learning (ML), material traceability, optimization, advanced control, and cyber-physical security, have been developed and implemented into the continuous pharmaceutical manufacturing process.

Four machine learning (ML) models have been trained to predict the response of continuous pharmaceutical manufacturing process and the performance of these ML models has been compared. The investigated ML methods are long short-term memory (LSTM), 1D convolution neural network (CNN), random forest (RF), and artificial neural network (ANN). The best performing ML model is then implemented into the continuous pharmaceutical tablet manufacturing process for real time prediction.

A systematic framework including the methods and tools have been developed for material traceability. A corresponding software tool has been also developed to automate the material traceability procedure. The heart of the material traceability toolbox is the RTD model. The applications of the developed methods and tools have been demonstrated for material traceability of continuous pharmaceutical manufacturing process.

A systematic framework including the methods and tools has been developed for dynamic optimization of the feeder refill strategies. The deviation of the outlet mass flow of the feeder from the targeted flow rate has been minimized to obtain the optimum value of the feeder refill parameters. The material properties also affect the refill strategy meaning that the feeder refill strategy need to be frequently optimized if there are any changes in the materials and plant. Therefore, the developed feeder model and dynamic optimization tool can save the time and recourses as well as can improve the product quality significantly.

An advanced model predictive control (MPC) system has been implemented in the continuous pharmaceutical manufacturing (CPM) pilot-plant. The CPP’s and CQA’s are controlled in real time. The critical control variables that have been controlled using model predictive control (MPC) system are drug concertation, powder level before tablet press, main and pre compression forces, tablet weight and hardness. A novel control strategy for powder level control in a chute placed in between blender and tablet press unit operation of continuous tablet manufacturing process has been developed, implemented and evaluated.

A systematic framework including the methods and tools have been also developed for proactive identification and mitigation of potential cyber-physical attack risk on continuous pharmaceutical manufacturing plant [2]. The cyber-physical security relevant software tools such as Snap 7, Wireshark, and Tripwire have been applied to CPM. A novel software tool named CPS (Cyber-Physical Security) has been developed for cyber-physical security of the continuous pharmaceutical manufacturing. The integrated commercially available and developed (in house) cyber-physical security tools have added an extra layer of security of our continuous pharmaceutical manufacturing pilot-plant for any unexpected attacks.

All the relevant data generated during continuous manufacturing has been systematically collected, stored and organized in a data hub (OSI PI) and cloud system as per industry 4.0 standard.

References

1. Bhaskar, A., Barros, F. N., Singh, R. (2017). Development and implementation of an advanced model predictive control system into continuous pharmaceutical tablet compaction process. International Journal of Pharmaceutics, 534 (1-2), 159-178.
2. Billups, M., Singh, R. (2018). Systematic framework for implementation of material traceability into continuous pharmaceutical tablet manufacturing process. Journal of Pharmaceutical Innovation. https://doi.org/10.1007/s12247-018-9362-9.
3. Singh, R. (2021). Cyber-Physical Security (CPS) Tool for Continuous Pharmaceutical Manufacturing Process. Pharma Focus Asia. Issue 44, 41-49. https://www.pharmafocusasia.com/information-technology/cyber-physical-se....