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Biogas is an attractive energy source for a sustainable hydrogen production. Because of the predominant concentration of CH4 (50%~80%) in biogas, a conventional reforming process can upgrade biogas into value added products such as syngas or hydrogen. However, it is hard to determine the optimal process configuration of the biomass-to-hydrogen process due to the uncertainty of the fed biogas composition. Furthermore, the optimal operating conditions of the involved unit processes are also sensitive to the CH4 concentration. Such uncertainty of the feed gas requires a number of process simulation and evaluation studies to assess various pathways that produce hydrogen from biogas. Therefore, an early-stage evaluation of the performance of the biomass-to-hydrogen process that is capable of considering the effects of a biogas composition to the economics, energy efficiency and environmental impacts. Here, we introduce the data driven model for early stage assessment of hydrogen production from biogas without whole process simulation and a required optimization. First, we preliminary developed a process model of various reforming technologies based on a wide range of biogas compositions. Using obtained data from simulation, we could generate parameters that contain the information of mass and energy balance. We also made a huge database (economic and technical parameters) of the following unit processes (e.g., amine-based CO2 separation and hydrogen purification) by developing simulation models. Finally, we employed data from the results of process simulation and performed sensitivity analysis under four different techno-economic and environmental evaluation criteria: Unit production cost (UPC), energy efficiency (EE), net CO2 equivalent emission (NCE) and maximum H2 production (MHP). As a result, it was revealed that although when a low CH4 concentration biogas is fed, a steam methane reforming process has economic merits, other reforming processes show better performance in the environmental aspect and energy efficiency. Our preliminary research indicates that the early stage evaluation of the biogas-to-hydrogen process can guide to establish biogas utilization strategies in various locations and conditions and, propose effective biogas enhancement process development solution to respond market disturbances.