(102f) 3D Printable Biodegradable Polymers for Medical Applications

This study presents the design and fabrication of multi-channel nozzles using 3D printing technology, which were utilized to guide biocompatible feedstock for the production of a double-layered vascular graft. The resulting graft exhibited nonlinear elasticity attributed to its flower-mimicking geometry. Natural polymers, including methacryloyl gelatin (GelMA) and sodium alginate, were employed for the vessel wall of the graft, demonstrating high biocompatibility and cell adhesion in vitro. By leveraging 3D printing techniques, this project efficiently achieved biomimetic mechanical properties while offering flexibility in implementing various geometries. These findings highlight the potential of individualized medicine and advanced treatment approaches for coronary artery disease.