(131a) Invited Talk: Biomimetic Mechanobiology: Measurement-Driven Design of Mechanically-Responsive Biomaterials for Tissue Engineering Applications
AIChE Annual Meeting
2024
2024 AIChE Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Engineered Biomimetic Tissue Models III: Microenvironmental Control for Biomimetic Models
Monday, October 28, 2024 - 12:30pm to 1:10pm
The process by which we grow from homogenous embryos into functional tissues and organs is a manufacturing marvel. Mechanical forces must play a central role in tissue formation during development, and in tissue disruption during disease; but the tools to measure, manipulate, and recreate these potent stimuli have lagged far behind the explosive growth of molecular biology techniques. The Moraes lab engineers realistic microscale tissues âon-a-chipâ using a variety of microfabrication, biomaterials, and computational approaches, to (1) watch the co-evolution of complex biomechanics, tissue specification, and biological function;and (2) use these insights to develop new tissue engineering and diagnostic strategies. Here, I will describe how this general approach has allowed us to design new mechanically-responsive biomaterials to consistently maintain desired mechanical stresses in organoid models, as a mechanical control mechanism for induced pluripotent stem cell differentiation and tissue maturation.