(282a) Advances in Population Balance Modeling and Simulation

Population balance modeling has been a key tool in the understanding, design, and control of a wide variety of processes including crystallization, precipitation, aerosol formation, and bioreactors. While the overall framework was developed more than a half century ago, innovations in numerical algorithms have continued to occur and the number of new applications has continued to grow. This talk will describe some of these developments, both in terms of new application areas such as in gene therapy manufacturing and in terms of numerical algorithms which, in some cases, have orders of magnitude reductions in calculation time. The latter have enabled population balance models to be incorporated into optimal control algorithms that are computable in real time on cheap control hardware.