(344f) Systematic Characterization of Interfacial Properties of Lipid Nano Carriers of Ternary Lipids (DSPC, Cholesterol and SM-120)
AIChE Annual Meeting
2024
2024 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Enabling Technologies Relevant to Drug Substance
Tuesday, October 29, 2024 - 2:15pm to 2:36pm
Abstract #692992
Systematic Characterization of Interfacial Properties of Lipid Nano Carriers of Ternary Lipids (DSPC, Cholesterol and SM-120)
Natsuumi Ito1, Yamaguchi Kouta1, Nozomi M. Watanabe2 and Hiroshi Umakoshi2, (1)Div. of Chem. Eng., Grad. Sch. of Engineering Science, Osaka University, Toyonaka, Osaka, Japan, (2)Div. of Chem. Eng., Grad. Sch. of Eng. Sci., Osaka University, Toyonaka, Osaka, Japan
Abstract Text:
Nanostructured lipid carriers (NLCs) are a new generation of lipid vectors for drug delivery systems (DDSs), which are composed of solid and liquid lipids dispersed throughout the inner lipid matrix. This study provides a systematic method to characterize the interface of the NLC. Twitterionic lipid (DSPC), cholesterol and cationic lipid (SM102) were selected as the target NLC. After the preparation of the NLCs with different compositions, the obtained NLCs were applied to (1) Physical Property (DLS), (2) Physicochemical Properties (Steady-State Fluorescence Analysis: Hydrophobicity and Fluidity with Phase State Estimation based on Previous data), and (3) Surface-Hydrated Properties (Time Resolved Emission Spectra Analysis). A series of data set for various NLCs were shown in different triangle diagrams of the above three components. These systematic results can be used to clarify the design space of the NLC composition to show the appropriate interfacial properties for DDSs.
