(368bf) Engineering Nano-Encapsulated Bioactive Systems for Effective Combat Against Agricultural Pests and Foodborne Pathogens

Insect infestation incurs an annual production loss of $17.7 billion on agricultural crops. Enhancing agricultural productivity necessitates the implementation of advanced crop-protection practices that offer highly effective treatments against these pests, ensuring both increased efficacy and environmental safety. To do so we have explored utilization of nanobiotechnology in the field of agronomy. Nano-encapsulation of bioactive compounds facilitates enhanced efficacy by increasing the available surface area, thereby promoting interfacial interactions with target sites improving the bioavailability by enhancing solubility and dispersibility of the bioactive compounds in aqueous media. Additionally, it not only facilitates better cellular uptake and biodistribution through the intracellular and extracellular plant- channels but also enables targeted delivery of certain parts of the plants, thereby optimizing the therapeutic effect. Therefore, on a global scale, the adoption of innovative nano-biopesticides is a sustainable practice due to their potential for enhancing environmental safety and targeted efficacy. In our investigation, we have conducted a fundamental study to model the interaction of seven different food-grade encapsulants commonly used in the formation of nanopesticides with the plant-epicuticular wax substrates. Through this investigation, we have identified suitable encapsulants tailored to specific functions within the agrochemical industry.

Post-harvest contamination of food commodities by air and waterborne pathogens is a prevalent issue attributed to inadequate sanitation practices, contaminated food-contact surfaces, and improper handling procedures. According to the Centers for Disease Control and Prevention (CDC), the United States experiences approximately 48 million cases of foodborne illnesses and 3,000 associated deaths annually. Within the food processing industry, cross-contamination represents a significant concern, as it can lead to the widespread contamination of entire batches of produce, necessitating extensive recalls of processed foods. Hence, addressing both pathogenic infestation of food commodities and extending their shelf life is crucial for enhancing their utility and facilitating exports to distant countries. To tackle these challenges, we have developed robust, food-safe superhydrophobic coatings suitable for application on food contact surfaces. Additionally, we have formulated nano-bioactive-infused hybrid wax coatings designed for use on fruit and vegetable commodities. Through this endeavor, our objective is to achieve a 99% reduction in the adhesion, proliferation, and cross-contamination of foodborne bacteria, thereby ensuring optimal safety for end consumers.

Hence, by utilizing the concepts of nano-bio-technology, our objective is to promote sustainability, safety, and ecological integrity.