(640a) Invited Talk: Electrochemical Impedance Spectroscopy, without Redox Mediators, for Detecting Chemicals and Proteins

The Surface Enhanced Electrochemical Diagnostics Sensors (SEEDS) Lab has been developing soft matter dynamic surfaces for applications in chemical and biosensors. One surface is a cyclodextrin mediated surface that decouples when exposed to an analyte. Another surface uses elastin-like polymer temperature response to look at different surface states. One common thread in our surface construction is that no electrochemical mediator exists to clearly interpret a faradaic signal commonly seen in voltammetry or amperometry.

My group has been actively working with electrochemical impedance spectroscopy (EIS), without redox mediators, to confirm the different surface states towards point-of-need biosensors. We will present our past success, our collaboration across BIO-SENS (Bio-Inspired On-demand Strategies for Engineering Nanostructured Sensors) using EIS for new protein surface recognition elements, and our progress in interpreting EIS response without redox mediators.