Controlling Second Phase Fall-out from a Homogeneous Mixing Process
Process Development Symposium
2021
2021 Process Development Symposium
General Submissions
Development in the Age of Tech Transfers and Outsourcing
Wednesday, June 9, 2021 - 2:00pm to 2:30pm
In the production of a critical intermediate, a hydrophobic diluent and an amphiphilic active species are mixed, causing an immiscible second phase to fall out of solution. Critical to product quality, the intermediate must be a clear solution free of second phase material. Scaled-down lab work was completed to optimize the mixing and separation process and identify the amount and character of the second phase. As expected, mixing intensity and order of addition played an important role in separability of the second phase. Unexpectedly, ingress of a small amount of water was also shown to be critical to final product quality. This knowledge was key to explain past observations in production, and the potential of a reappearing second phase if the process is mishandled.
Checkout
This paper has an Extended Abstract file available; you must purchase the conference proceedings to access it.
Do you already own this?
Log In for instructions on accessing this content.
Pricing
Individuals
AIChE Pro Members | $695.00 |
AIChE Graduate Student Members | $695.00 |
AIChE Undergraduate Student Members | $695.00 |
AIChE Explorer Members | $895.00 |
Non-Members | $895.00 |