Kinetic Parameter Development for Integrated Custom Model Flowsheeting
Process Development Symposium
2021
2021 Process Development Symposium
Poster Session
Poster Networking Session
Wednesday, June 9, 2021 - 2:30pm to 3:00pm
In the production of a critical intermediate, a hydrophobic diluent and an amphiphilic active species are mixed, causing an immiscible second phase to fall out of solution. Critical to product quality, the intermediate must be a clear solution free of second phase material. Scaled-down lab work was completed to optimize the mixing and separation process and identify the amount and character of the second phase. As expected, mixing intensity and order of addition played an important role in separability of the second phase. Unexpectedly, ingress of a small amount of water was also shown to be critical to final product quality. This knowledge was key to explain past observations in production, and the potential of a reappearing second phase if the process is mishandled.
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