Exploiting Microbial Cell Factories for the Development and Manufacturing of Novel Biologics and Industrial Products

Establishing bioprocesses to manufacture valuable biologics and industrial products in microrganisms requires the design, construction and optimisation of strain productivity and stability, fermentation and efficient DSP. This presentation will exemplify Ingenza’s integrated toolbox of enabling technologies in industrial biotechnology and engineering biology. Ingenza’s combinatorial genetics (inABLE^®), genome editing, advanced HTP screening methods, FACS-assisted optimization of protein expression and tailored fermentation protocols combine to rapidly demonstrate bioprocess feasibility to meet manufacturing requirements. Case studies will be focused on directed evolution of novel enzymes, cost-competitive recombinant production of a first-in-class antibacterial peptide and establishment of a plug-and-play microbial vaccine platform meeting future global needs. Our bioengineering technologies are bringing increased predictability to overcome persistent limitations associated with strain improvement, enabling rapid progression to process optimization and scale-up for applications.