The ability to control chemical reactions to efficiently and selectively produce the desired products has vastly improved over the past decades, with increasingly sophisticated techniques now available to dictate the outcome of these reactions. While much progress has been made, much more is needed to realize a perfect reactor, which would allow for full control of chemical transformations at the molecular level. In the October AIChE Journal Perspective article, “Practical Challenges in Energy-Based Control of Molecular Transformations in Chemical Reactors,” Andrzej Stankiewicz, Izabela Szydłowska Franssen, Daniel Irimia, and Georgios Stefanidis of Delft Univ. of Technology expand on this topic of molecular control in chemical reactors.