Effect of Heat Treatments On Stability of Penicillin G in Waste Penicillium Chrysogenum

Penicillin G (PENG) is one of the most widely used bacteriostatic antibiotics in human and veterinary medicine. . It may cause biological drug resistance and environmental toxicity. In this study, we investigate the degradation efficiency of PENG by heat treatment. A kinetic study was performed under different temperature conditions (60°C, 70°C, 80°C, 90°C and 100°C). The first-order rate constants for the direct reaction of PENG with heat treatment were measured to be 0.008 to 0.027 under the temperature conditions tested. The rate constants were greater at higher temperature. These results suggest that higher temperature conditions and short term are needed for the removal of PENG by heat treatment in order to mitigate the residual toxicity that can remain in waste penicillium chrysogenum manufactured during the penicillin pharmaceutical process