The Mimee Lab leverages synthetic biology to engineer the microbiome, exploring strategies to modify commensal bacteria and bacteriophage for diagnostic and therapeutic applications.By genetically manipulating commensal microbes, we seek to create living devices that can serve as biosensors to probe the structure and function of the microbiome and as cell-based therapeutics for infectious and inflammatory disease. Additionally, we develop approaches to augment the natural properties of viruses that infect bacteria, called bacteriophage, to create novel therapies for antibiotic-resistant bacterial infections. Our long-term vision is to implement these synthetic biology technologies to chart new basic and translational studies to exploit the microbiota for human health.