Professor Steven Cramer is an Institute Professor at Rensselaer Polytechnic Institute, Troy, New York. The Cramer lab’s research over the past 37 years has helped to improve the state of the art of downstream bioprocessing and its successful implementation for the biomanufacturing of biological products. Current research in the Cramer lab using a combination of biophysics, molecular dynamics simulations and chromatography with ligand protein libraries has provided insights into the design of novel multimodal chromatographic systems. Recent work on integrated biomanufacturing and expedited process development is having an impact on how bioprocess development is carried out in the industry. The Cramer lab is now actively involved in gene therapy downstream biomanufacturing projects, continuous mRNA processing, and several big data modeling efforts. Professor Cramer has won numerous awards including the Gordon Prize from the National Academy of Engineering, ACS National Award in Separations Science and Technology, the ACS BIOT Division’s Michaels Award in the Recovery of Biological Products, the Gaden award from the Biotechnology and Bioengineering Journal, and several awards from RPI including the Wiley Distinguished Faculty Award and the School of Engineering Outstanding Professor and Research Excellence Awards. Cramer has been elected a member of the National Academy of Engineering and U.T. Austin’s Academy of Distinguished Chemical Engineers. He is also an elected fellow of the American Association for the Advancement of Science, American Institute of Chemical Engineers, the American Chemical Society, and the American Institute for Medical and Biological Engineering. He has published extensively in the field with more than 250 publications, and the 60 Ph.D. graduates from the Cramer lab have had a significant impact with many of his former students now playing key leadership roles in the state of the art of industrial bioprocessing at most of the major biopharmaceutical and bioseparations companies worldwide as well as academia.