(101c) Monitoring the Hydrolysis of Acetic Anhydride Using in-Situ Raman Spectroscopy and Novel Multivariate Data Analysis – Band-Target Entropy Minimization (Btem)
AIChE Annual Meeting
2005
2005 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Advances in Continuous Pharmaceutical Analysis and Processing
Monday, October 31, 2005 - 3:55pm to 4:15pm
With the increasing demand for novel process analytical technologies in recent years, Raman spectroscopy has been one of the powerful choices for in-situ reaction monitoring. In this paper, we discuss the use of in-situ Raman spectroscopy and novel multivariate data analysis method namely band-target entropy minimization (BTEM) to monitor the hydrolysis of acetic anhydride to acetic acid. In-situ Raman spectroscopy is employed to continuously measure the spectrum of reaction mixture in every 2 minutes for a few hours time. The collected spectra are then subjected to BTEM in order to elucidate the pure component spectra and the concentration profiles of the observed components. In addition, a comparison study between univariate and multivariate data analysis on the reaction spectra is also presented.
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2005 Annual Meeting
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