(392b) Continuous Centrifugation of Adenovirus Infected Cell Culture Lysates
AIChE Annual Meeting
2005
2005 Annual Meeting
Separations Division
Centrifugal Field-Enhanced Bioseparations
Wednesday, November 2, 2005 - 3:45pm to 4:15pm
Continuous centrifugation was evaluated as a clarification option for large-scale purification of adenovirus from detergent-precipitated cell culture lysates. When compared to depth filtration alone, centrifugation followed by polishing depth filtration provided comparable clarification with benefits of contained processing, automated operation, and a potential increase in process robustness.