(43e) Measurement of Solubility of Ibuprofen and Flurbiprofen Enantiomers in Carbon Dioxide Mobile Phase with Iso-Propanol and Sec-Butanol Employed as a Modifier

Separation of chiral isomers of ibuprofen and flurbiprofen, non-Steroidal Anti-Inflammatory Drugs (NSAID), is performed using a sub- and supercritical fluid chromatographic system. Carbon dioxide is used as a mobile phase with iso-propanol and sec-butanol employed as a modifier. For modeling these systems, solubility information is crucial. The solubility of each compound is determined using a phase analyzer from Thar Technology. Cloud points of ibuprofen and flurbiprofen are determined in pure supercritical carbon dioxide and mixtures of carbon dioxide and the alcohol modifier. Cloud point measurements are performed at different operating temperatures and pressures. The results are modeled using PRSV and extended to other experimental condition.