(266f) Novel in-Situ Hybrid Hydrogels of Hyaluronic Acid, Cellulose Derivatives, and Dextran to Prevent Peritoneal Adhesions

A postoperative peritoneal adhesion causes pelvic pain, bowel obstruction and fertility. We synthesized many polymers such as hydrazide-modified hyaluronic acid (HA-ADH), hydrazide-modified carboxymethyl dextran (CMD-ADH), aldehyde-modified dextran (DEX-ALD), aldehyde-modified carboxymethylcellulose (CMC-ALD), aldehyde-modified hydroxypropylmethyl cellulose (HPMC-ALD), and aldehyde-modified methyl cellulose (MC-ALD). These above polymers formed hydrogels quickly by mixing hydrazide polymers with aldehyde polymers. Various combinations of different polysaccharides can make the design of the hydrogels properties such as swelling and degradation. Besides, these hydrogels showed good biocompatibility in mice peritoneum for 3weeks in vivo. Finally these hybrid hydrogels were tested using a rabbit sidewall defect-bowel abrasion model.