(364g) Synthesis and Characterization of Moiety Imprinted Polymers (Moips) for Application in Drug Delivery

For control over loading and delivery of a desired pharmaceutical compound, moiety imprinted polymers (MoIPs) are a novel alternative to imprinting for entire drugs. For this approach, a moiety of the drug is used as the template instead of the entire drug. Molecularly imprinted polymers have been shown to have a higher affinity for a target molecule as a result of the recognition sites. This high affinity can be used to increase loading and to control release of a drug. Here, MoIPs have been shown to have a higher affinity for both the moiety (template) and the entire drug compound. Specifically, the synthesis and characterization of moiety (D-glucose) imprinted polymers for application in drug delivery were studied. The swelling, loading, and release of a model drug (Phenyl-ß-D-glucopyranoside) were analyzed. The potential of MoIPs to increase affinity for a model drug over a nonimprinted polymer was demonstrated.