(439f) Bioavailability Estimation of Alginate/Chitosan Capsules Using a Simulated Human Intestinal System
AIChE Annual Meeting
2006
2006 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Drug and Gene Delivery Poster Session
Wednesday, November 15, 2006 - 3:15pm to 5:45pm
Plant polyphenol compounds have been considered nutritionally important recently. However, achieving successful delivery of flavonoids and phytoestrogens via the oral route is particularly difficult, due to the formiable enzymatic and transport barriers in the gastrointestinal tract. There are so far no delivery systems for foods which designed to enhance the efficiency and stability of bioactive agents. In the present study, we assembled a simulated human intestinal system (SHIS) which consists of stomach and small intestine. In order to prepare the alginate/chitosan capsule as a delivery system of bioactive agents, the microencapsulation system was assembled with control unit, electrical and pneumatic systems and reaction vessel. The stomach chamber was initially filled with gas fluids and then digested for 2 hrs. After the stomach digestion, the residuals was delivered from stomach chamber into the small intestine chamber by secreting intestinal fluid for 4 hrs, followed by secretion of 0.3M NaHCO3, 0.1M NaHCO3, 4% bile salt and 2% bile salt for 1, 3, 0.5 and 3.5 hrs, respectively. After digestion of alginate capsules, the content of total sugar were 7.47% and 60.82% in the stomach and small intestine, respectively. However, in case of alginate/chitosan capsule and alginate/chitosan-PAE coated capsule, the total sugar were 3.12 and 4.62 % in the stomach and 43.46% and 42.09% in the small intestine, respectively. There were no difference on the degree of digestion in the alginate capsule and alginate/PEG capsule prepared with 0.1 ~ 0.3% of PEG in the stomach. The digestion kinetics were also investigated in comparison with a starch, soy protein isolate and catechin in the SHIS.
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2006 Annual Meeting
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