(304e) Mathematical Modeling of Oxygen Distribution in Cornea with Contact Lens

Since 1991, multi-layer mathematical in-vivo oxygenation models have been created in order to predict normal corneal oxygenation with contact lens wear. From these models, there have been assertions that most hydrogel contact lenses allow 97-98% of normal corneal oxygenation; compared to no contact lens wear. In light of hydrogel neovascularization and limbal hyperemia, to clinicians, this finding seems counter-intuitive.

This work seeks to validate or refute those preexisting models and estimate the impact of contact lens wear on the oxygen distribution profile across the cornea. To this end, a 2-D axisymetric finite element analysis (FEA) model was constructed for contact lenses, on the cornea; both having varying thickness profiles. The oxygen permeability, material thickness profile, and oxygen consumption coefficients from Brennan (O&VS 6/05) are used for model validation.

Further development includes the use of various kinetic models (e.g. monod) to approximate oxygen consumption. Distribution of oxygen partial pressure, oxygen flux, and consumption profiles are presented for each kinetic model for purposes of comparison with clinical data.