Effect of Particle Size Distribution on the Tablet Properties

ABSTRACT

In pharmaceutical manufacturing powder compaction is very important, since tablets generally are formed by compression of a powder, held in a confined space, by

mechanical treatment. The technology of mechanical powder processing have consequently involved as important parts of formulation science. The importance of the initial size of the particles constituting a powder in determining compaction behavior has long been recognized. However, the influences are often conflicting. For most powdered pharmaceuticals, compaction of smaller particles results in stronger tablets because the smaller particles provide a larger total area for bonding than larger particles. However, the effects of the initial particle size on the strength of tablets depend on the mechanical properties of the materials