(116as) Evaluation of Method Precision and Sample Homogeneity in Novel Gel Strip Formulation Analyzed by NIR Spectroscopy

The purpose of this project is for the determination of drug homogeneity in gel strips. This novel technology of gel strips is used as a tool that prevents agglomeration of the drug and the distribution of the particles throughout the polymer. These results will provide the necessary information for the ability to determine the precision, of this method. Repeatability is expected for a successful method. With the use of a multipurpose Analyzer (MPA) Fourier Transform Near Infrared (FT-NIR) Spectrometer (Bruker Optics) equipped with a lead sulfide detector, an integrating sphere (external transmission) and with a beam size of 4 mm diameter, spectra were obtained for a 100 micrometer thick gel strips. A smaller beam size in the NIR Spectrometer was used because it provides a more precise result. The scale of scrutiny proves that the larger the area chosen to work with, the most general result will be obtained. In this case, because the area used has a diameter of 4mm instead of 15 mm used in previous experiments. Initial results are presented using a 15 mm NIR beam diameter which shows more homogeneity in the gel strips. The spectra obtained with the 4 mm beam are expected to show less homogeneity as they analyze a smaller sample area. The final results will be presented in the poster.