(364g) Modeling Buffer Preparation Operations for Downstream Processing
AIChE Annual Meeting
2008
2008 Annual Meeting
Separations Division
New and Improved Chromatographic Resins and Processes for Bioseparations
Tuesday, November 18, 2008 - 5:03pm to 5:21pm
In most biopharmaceuticals processes, the downstream purification is dominated by chromatographic separations, which require the preparation, holding and distribution of numerous buffer solutions. Buffer preparation is a potential process bottleneck in high-capacity situations. This paper examines the use of macroscopic modeling techniques to evaluate buffer preparation for downstream processing. Cases studies will address the challenges in buffer preparation for multi-line facilities (that share buffer prep tanks), the impact of disposable containers on the demand for utilities and the cost of goods, and the effect of changes in bioreactor titer.