(615c) Microwave-Assisted Synthesis of α-Hydroxy Aromatic Ketones From α-Bromo Aromatic Ketones
AIChE Annual Meeting
2009
2009 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Innovations in Pharmaceutical and Biopharmaceutical Process Development
Thursday, November 12, 2009 - 3:51pm to 4:09pm
In the synthesis of various natural products and pharmacologically active compounds, α-hydroxyketones are potentially valuable synthetic intermediates for the preparation of a range of compounds of biological products. We have developed a very clean, simple and convenient method for the synthesis of α-hydroxyketones. A novel reaction of α-bromo aromatic ketones with irradiation under microwave gave the corresponding α-hydroxy aromatic ketones in excellent yields (85-95%). The synthesis of α-hydroxyketones was irradiated by microwave (200W) in water and pressure (0.3 MPa) at 110 oC for 25 min, which was more convenient than the method used heretofore. The use of microwaves was found to significantly improve the reaction yields and shorten the reaction time.
Checkout
This paper has an Extended Abstract file available; you must purchase the conference proceedings to access it.
Do you already own this?
Log In for instructions on accessing this content.
Pricing
Individuals
2009 Annual Meeting
AIChE Pro Members | $150.00 |
AIChE Graduate Student Members | Free |
AIChE Undergraduate Student Members | Free |
AIChE Explorer Members | $225.00 |
Non-Members | $225.00 |
Food, Pharmaceutical & Bioengineering Division only
AIChE Pro Members | $100.00 |
Food, Pharmaceutical & Bioengineering Division Members | Free |
AIChE Graduate Student Members | Free |
AIChE Undergraduate Student Members | Free |
AIChE Explorer Members | $150.00 |
Non-Members | $150.00 |