(437d) Application of in-Situ Technology in 2,6-Diamino-3,5-Dinitropyrazine-1-Oxide (LLM-105) Recrystallizations

The increased knowledge gained through the use of in-situ technologies is invaluable in determining the best method of obtaining the desired particle size and morphology of 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) in recrystallization processes. Extensive experimentation performed at the Indian Head Division, Naval Surface Warfare Center (IHD NSWC) has shown the advantages and the usefulness of having this technology in understanding the recrystallization of LLM-105 from several different solvent systems. Differing methods of inducing nucleation have also been studied. A focused beam reflectance and measurement (FBRM) probe measures the particle size counts and distributions of LLM-105 crystals, and offers valuable insight. In addition, a particle vision and microscopy (PVM) probe allows real time images to be collected of the solid material in the slurry. Several case studies will be presented that highlight the knowledge and value gained from the use of these probes.