(444d) Characterization of Feeder Effects On Continuous Powder Mixing Using Fourier Series Analysis
AIChE Annual Meeting
2010
2010 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Applications of Continuous Processing in Manufacture of Drug Product
Wednesday, November 10, 2010 - 1:35pm to 1:55pm
Continuous powder mixing attenuates feeding
fluctuations while reduces transverse heterogeneity of initial segregated
components [1]. Although the capacity of the mixer to smooth out feeder fluctuations can be generally characterized by the variance reduction ratio (VRR) at the input and output of the mixer [2-4], few studies are performed quantitatively in illustrating this attenuation process. This leads to inconveniency in selection or improvement of integrated feeder-mixer system if it is not optimal.
In this study, the feeder effects on the
solid mixer are investigated through Fourier series analysis. The VRR is deduced
using the Fourier series of the feed rate and the residence time distribution
(RTD), which facilitate the VRR to be explicitly decomposed into different
frequency components. By analyzing the feeding variance and the filtering ability
of the mixer to reduce the variance in different frequency domains, the model
provides a novel method to determine whether the integrated feeder-mixer system
satisfies specific powder mixing performance criteria, and provides specific guidelines
for system improvement.
Based on the developed method, the influence
of Peclet number (Pe) and the mean residence time (¦") of the
Taylor dispersion model on the filtering ability is investigated. The results
suggest that large ¦" and small Pe lead to good filtering ability.
The method also provides general feeder performance criteria, which can be
effectively used in the improvement of feeder design. Experimental results
are used to illustrate how specific guidelines can be suggested based on the
proposed Fourier series method.
Reference
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J.C. and M.A. Rahman, Prediction of the performance of continuous mixers for
particulate solids using residence time distributions : Part II. Experimental.
Powder Technology, 1972. 5(5): 307-316.
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Weineköter, L.R., Continuous Mixing of Fine Particles. Particle and
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