(571j) Comparison of Tablet Dissolution Using USP Apparatus II and TIM-1 Gastrointestinal Compartment
AIChE Annual Meeting
2010
2010 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Poster Session: Pharmaceutical Engineering
Wednesday, November 10, 2010 - 6:00pm to 8:00pm
The overall goal of pharmaceutical dosage forms is to deliver the proper therapeutic dosage of drug over the proper length of time. To characterize this release, the most common method used is dissolution in a USP II apparatus. Previous research has shown this technique to be quite lacking in terms of predicting actual drug release in vivo. Alternatively, the relatively new TIM apparatus provides a more sophisticated modeling of the human gastrointestinal system. Model pharmaceutical tablets were produced and dissolved in both systems and the resultant dissolution profiles compared. In addition, CFD models of the fluid flow in the TIM stomach compartment were compared to previously published CFD models of the USP II apparatus to determine the effects of fluid shear on dissolution. This was used in conjunction with a 3-D mechanistic model of tablet erosion and dissolution to determine the parametric differences between the two dissolution techniques and determine the effective correlation points between them.
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2010 Annual Meeting
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Food, Pharmaceutical & Bioengineering Division only
AIChE Pro Members | $100.00 |
Food, Pharmaceutical & Bioengineering Division Members | Free |
AIChE Graduate Student Members | Free |
AIChE Undergraduate Student Members | Free |
AIChE Explorer Members | $150.00 |
Non-Members | $150.00 |