(191y) Comparative Study of Aggregation Behavior of Griseofulvin, Naproxen, and Fenofibrate In Binary Film Precusor

Aggregation behavior of active pharmaceutical ingredient (API) in biopolymer network plays an important role in control release. One of the most important factors that affect the aggregation of API in polymer matrix is the interaction of polymer – surfactant – API particles. The aggregation of API submicron particles on different mixture low viscosity hydroxypropyl methyl cellulose (E15LV) with other biopolymers in anionic and non-charge surfactant solutions is investigated. Four biopolymers such as high viscosity hydroxypropyl methyl cellulose (E4M), gelatin A, gelatin B, and chitosan are used. Naproxen and Fenofibrate submicron size particle serve as API particles.  Our data shows that the particle size of API is in order gelatin A > chitosan > gelatin B> E4M. Dynamic light scattering technique is applied to analyze particle size of API particles and their zetapotential in different mixture of biopolymer solutions. SEM is used to reveal the arrangement of API particle in the film matrix. The interaction of polymer – polymer and polymer – surfactant in these mixtures is analyzed by surface tension and rheology measurements. A sensitive gravimetric system is exploited to detail the drying kinetic of those considered mixtures.