(32f) Utilizing Drop-On-Demand Printing In the Manufacture of Transdermal Dosage Forms

We propose to utilize Drop-on-Demand technology to manufacture transdermal drug delivery systems (TDDS) in an innovative and systematic approach.  The primary goal is to decrease the amount of layers currently used in the traditional system and create new dosage forms by printing the API, skin enhancers, additives, and adhesive components onto the same film with distinct patterns and configurations to achieve the desired bioavailability and controlled release rates.  Previous research has detailed that manipulation of substrate properties can be used to control the morphology of the API deposits and obtain API forms ranging from amorphous to crystalline structures.  This study establishes the relationships between the API and polymer film properties, kinetics of the evaporation process, final stain morphology, solubility properties of the fabricated dosage, and API dissolution.    Ultimately this research will enable the development of scientific fundamentals which allow us to accurately create novel API dosage forms where the final droplet structure exists as defined two and three dimensional architecture with a controllable release profile.