(569b) Nanoparticle Induced Pore Formation On Supported Lipid Bilayer

Most of recent research on the drug delivery and ytotoxicity of nanomaterials with cell membranes has focused on hydrophilic nanomaterials because of their good dispersion in water, but much less on hydrophobic ones. In this work, we have investigated the effect of semi-hydrophobic nanoparticles (NPs) on the dynamics and morphology of model cell membrane. We have found carboxyl functionalized polystyrene nanoparticles can induce the formation of microscaled pores on neutral supported Egg PC lipid bilayer at the ionic strength range similar to that in the human body with a strong dependence of nanoparticle size and concentration. The hydrophobic interaction between the NP surface and lipid bilayer is accounted for the induced line tension in lipid bilayer; when the tension exceeds a critical value, nanopores are formed and grow rapidly with dependence on nanoparticle size and ionic strength.