(639b) The Detection of Cancer Biomarkers On Biosensor Surfaces

A fractal analysis is presented for the binding and dissociation (if applicable) of different cancer biomarkers to appropriate receptors immobilized on different biosensor surfaces. Some of the cancer biomarkers analysed include: (a) the binding of 10 Molv NIG 3T3 cancer cells in hyposomotic solution to a microelectrode (de la Rica et al, 2009), (b) binding of different concentrations CEA (carcinoembryonic antigen) in BSA-PBS solution to the anti-CEA antibody functionalized to a microring resonator biosensor surface (Washburn et al., 2009), (c) detection of telomerase over-expression for cancer diagnostics by an optical fiber nanobiosensor (Zheng and Li, 2010), (d) binding of 150 ng/mL the cancer biomarker interleukin-8 (IL-8) in solution to the anti-IL-8 antibody immobilized on a microring resonator biosensor surface (Washburn et al., 2009), (e) binding of the cancer biomarker, prostate specific antigen (PSA) in solution to the anti-PSA immobilized on a microring resonator biosensor surface (Washburn et al., 2009), (f) binding of the cancer biomarker, tumor-necrosis factor-a (TN-a) in solution to the anti-TNF-a antibody immobilized on the microring biosensor surface (Washburn at al, 2009), (g) binding of the cancer biomarker, carbohydrate antigen 125 (CA 125) to a nanoparticle-based sandwich electrochemical immunosensor (Tang et al., 2010), and (h) detection of the cancer biomarkers, galectin-3, galectin-4, and galectin-8 in solution to a protruding galactoside surface (Yoshioka et al., 2010).

Predictive relationships are developed for the binding and dissociation of the different biomarkers to the appropriate receptors immobilized on different biosensor surfaces. There is an urgent need and focus to help develop more sensitive and selective biosensors for cancer biomarker detection.