(164c) Scale-up Approaches to Preserve Particle Properties of Api's in Agitated Filter Driers

Agitated Filter Driers (AFD’s) are commonly used in the pharmaceutical manufacturing for performing both filtration and drying operations.  Successful scale-up from lab to manufacturing AFD equipment requires that the physical properties be met. These properties include product quality such as purity and particle size.  Depending on the API-solvent system and other operational parameters, undesired attrition or agglomeration may occur impacting the desired particle properties.  In such cases mitigation strategies are needed for scale-up that minimize agitation during drying while maintaining acceptable drying rates and ultimately preserving particle properties.  The focus of this presentation will be to describe our modeling and scale-up approaches into agitated filter driers with an emphasis on the challenging API’s with propensity for agglomeration or attrition during drying.

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