(403e) Characterization of Adhesion Between Chemical Robots and Biological Cells

Characterization of
Adhesion between Chemical Robots and Biological Cells

Viola Tokarova,*Frantisek Stepanek

Institute of Chemical Technology Prague,
Department of Chemical Engineering, Technická 5, Prague 6, 166 28, Czech Republic, *e-mail: frantisek.stepanek@vscht.cz

Composite microparticles or microcapsules for targeted
delivery of active substances such as antibacterial agents or pharmaceutical
compounds are of both practical and fundamental interest. The purpose of such
delivery vehicles is to store the active compound at a high concentration,
transport it through an environment in which the presence of the active
compound is not required (or not desirable), and eventually anchor to the target
site and release the encapsulated payload either spontaneously or upon an
external stimulus. For the design a targeted delivery system, not only the
release kinetics of the encapsulated compound from the microcapsule but also
the specific interactions of the microcapsules with the target point of
controlled release ?  their adhesion properties ? are crucial.

This work describes synthesis steps of such composite
microcapsule and their surface modification. The specific antigen-antibody
adhesion properties and characterization inside microfluidic cell will be
presented.